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KMID : 0848020040070020098
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Journal of Korean Breast Cancer Society
2004 Volume.7 No. 2 p.98 ~ p.103
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Different Expression of p27kip1 and p57kip2 by Genistein Treatment in MDA-MB-231 Human Breast Cancer Cells
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윤대성/Yoon DS
송기학/김성태/Song KH/Kim ST
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Abstract
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Purpose: The isoflavones in soy are likely to contribute to the historically low incidence of breast cancer among Asian women who consume traditional diets. The possible role of isoflavones in controlling the expression of p27kip1 and p57kip2 has not been previously explored. In this study, the ability of the isoflavone, genistein, to regulate the expression of p27kip1 and p57kip2 in breast cancer cells was evaluated.
Methods: The effects of genistein was examined on the expression of p27kip1 and p57kip2 at the mRNA level, using the MDA-MB 231 human breast cancer cell lines.
Results: By genistein treatment, p27kip1 mRNA increased significantly in comparison to the control group. In particular, p27kip1 mRNA level in 10μM and 50μM genistein treated- groups increased about two-folds more than the control . p57kip2 mRNA was not different from control group. p57kip2 mRNA decreased slightly only in the 50μM genistein treated-group. PPAR-γ mRNA level increased slightly according to the concentration-dependent manner of genistein, but it was not significantly different.
Conclusions: These results suggest that the up-regulated p27kip1 by genistein might contribute to cancer prevention or inhibition. (Journal of Korean Breast Cancer Society 2004; 7:98-103)
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